Biopoints of Failure
Just like JWST (James Webb Space Telescope) teams enumerated all possible signle-points-of-failure to compute spacecraft risk, enumerate all human organism (or bio-organism) points of failure, and strategize to reduce its failure risk.
It may be not so hard to start optimizing human organism for longevity as it seems -- simply start making a list of possible bio-organism points of failure to systematically eliminate with redundancies. This could start as a free web wiki, where points.of.failure.bio.
Let's create an on-line list of bio-points of failure: